As of right now, I've built new tools with tinkers' construct (using a Manyullyn Hammer/Excavator that I made from repeated nether trips), got a full-on smeltery that is 30 blocks tall, set up a steam dynamo, pulverizer, and induction smelter, and flown around as a ghast. My wife's currently setting up the biggest raspberry farm I've ever seen. Not sure how to get into advanced genetics or witchery...or make a ship.