I would say just liquids. Things like buttons, levers, torches would be valid things to put on a leading edge of a carraige, and knowing whether to move them or destroy them could get complicated.
As for colors, there's a few different types of colorblindness (short of not seeing color at all), and it'd be hard to make sure you had enough distinct colors for all. That being said, for me, the yellow and lime ones are indistinguishable from each other. If I had a sheet with all 16 colors I could pick out any other pairs, as shade can make a big difference. Taking wool for instance, in the default TP all 16 colors are distinct with Magenta and Purple being the closest, while in my TP Pink & Grey, and Light Grey & Cyan, are very hard to tell apart, if I can at all. Generally safe are colors 0, 1, one each of (2,3), (4,5), (6,7), (8,9), (10,11), (12, 13), 14, 15, but like I say, it varies greatly depending on the exact shades you use.