I have two big problems. First, my Resonant induction fusion reactor. It works for a bit, then just stops. Plasma goes in, no power comes out. Then it just becomes a power drain, the batteries in the loop just pump out all the power that they gained. Have to reload the game for it to restart, even then it's unreliable.
Second, The particle accelerator. I have a large enough power supply, a large enough ring, and have done a large amount of waiting. The pulses either cut out, or the game crashes. I can't get it to work. Best I've got is 96%. Then it stopped and restarted. No antimatter generated.