lol he doesn't want to "seal" it, he want's to use a bubble.
Yes it is possible. You will want to set up your bubble and your force field and then offset the forcefield dome the correct number of blocks so that it coincides with the center of your oxygen bubble.
From what I understand about what you are trying to do you should have complete mobility within your house and won't suffocate. That being said it might take quite a lot of power.... but that's part of the fun right? :)